| title: |
| Immunoglobulin G mediates chemoresistance to oxaliplatin in colon cancer cells by
inhibiting the ERK signal transduction pathway |
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| contributing persons: |
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| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
 |
38329-6 |
| Universitätsmedizin Rostock[Grad-verleihende Institution] |
|
1029510660 |
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| abstract: |
|
The aim of this study was to investigate the effect of therapeutically used immunoglobulin
G (IgG) on colon cancer in the presence of oxaliplatin. We observed that IgG failed
to significantly influence tumor cell viability and tumor growth; however, it significantly
inhibited the cytotoxic activity of oxaliplatin in vitro. In addition, we observed
that oxaliplatin-induced the activation of ERK; however, IgG inhibits ERK activity.
This implies that the application of therapeutical IgG to treating patients, which
are receiving oxaliplatin, might have harmful side effects.
[English] |
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| document type: |
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| institution: |
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| language: |
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| subject class (DDC): |
| 570 Life science |
| 610 Medical sciences Medicine |
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publication /
production: |
Rostock
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Rostock: Universität Rostock
|
|
2021
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| statement of responsibility: |
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| identifiers: |
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| access condition: |
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| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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| RosDok id: |
rosdok_disshab_0000002529 |
| created / modified: |
03.06.2021 / 08.08.2023
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| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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