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Felix Friedrich

Transdifferenzierung von Nebennierenrindenzellen in Abhängigkeit von ihren physiologischen Stimuli und Sekretionsprodukten

Universität Rostock, 2020

Abstract: It still remains unclear how the functional organisation of the adrenal cortex arises. One aim of this study was to create a setup which allows for the establishment of a concentration gradient in vitro. This was achieved by a continuous flow of medium through the culture flask which caused differences in glucose and cortisol concentrations as well as in pH values between the sites of inflow and outflow of medium. We wanted to answer the question whether a concentration gradient can regulate the differentiation of adrenal cells.

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