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Johann Volzke

Chronisch entzündliche und virale Vorerkrankungen sind Risikofaktoren der Streptokokken-induzierten septischen Arthritis

Universität Rostock, 2020

Abstract: Septic Arthritis (SA) is an infectious disease that leads to synovial inflammation and severe joint damage. Due to the lack of experimental models, it remains elusive how articular cells govern the elicitation of inflammation. Moreover, it is unknown in what way preceding diseases or co-morbidities influence on the occurence and severity of SA. This study demonstrated that synovial fibroblasts are capable of initiating inflammation. It was furthermore shown that preceding chronic inflammatory joint disease as well as influenca A infection significantly exacerbated SA.

doctoral thesis   free access