| title: |
| Defective myelination and its relative mechanism in Niemann-Pick type C disease |
|
| contributing persons: |
| Fan Yang[VerfasserIn] |
 |
1260687694 |
| Jiankai Luo[AkademischeR BetreuerIn] |
|
Universitätsmedizin Rostock |
| Rüdiger Köhling[AkademischeR BetreuerIn] |
 |
0000-0003-3330-4898 |
|
137585756 |
|
Universitätsmedizin Rostock |
| Thomas Pufe[AkademischeR BetreuerIn] |
|
123045371 |
|
Universitätsklinikum Aachen |
|
| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
|
38329-6 |
| Universitätsmedizin Rostock[Grad-verleihende Institution] |
|
1029510660 |
|
| |
| abstract: |
|
Niemann-Pick type C (NPC) disease is caused by mutations in npc1 or npc2 gene. In
this study, we found the maturation of NPC1-/- oligodendrocytes was significantly
inhibited, the myelin-related transcription factors Olig1 and Olig2 were downregulated
and the nucleocytoplasmic transport of p57Kip2 was inhibited in NPC1-/- oligodendrocytes.
Treatment of lovastatin reduced accumulation of cholesterol in the late endosomal
and lysosomal, increased the expression of Olig1 and Olig2, recovered the nucleocytoplasmic
transport of p57Kip2, and restored the maturation of NPC1-/- oligodendrocytes.
[English] |
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| document type: |
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| institution: |
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| language: |
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| subject class (DDC): |
| 500 Natural sciences |
| 570 Life science |
| 610 Medical sciences Medicine |
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| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2019
|
|
| statement of responsibility: |
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| |
| identifiers: |
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| |
| access condition: |
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| license/rights statement: |
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|
| RosDok id: |
rosdok_disshab_0000002746 |
| created / modified: |
23.06.2022 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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