Universität Rostock, 2021
Abstract: The members of the IGF system regulate growth at different levels. In the past, absolute concentrations of individual hormones were mainly used to describe the IGF system. According to current understanding, however, the analysis of the biological activity comes to the foreground for the description of the IGF system. In this work, the interaction of several factors is given greater consideration for the description of growth regulation in mouse lines selected for growth and in transgenic mouse lines. Furthermore, a bio-assay for in vitro analysis is presented.
doctoral thesis free access