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Fatemeh Shokraie

Defining the role of human endogenous retroviruses in pluripotency of colorectal cancer cells

Universität Rostock, 2021

https://doi.org/10.18453/rosdok_id00003975

Abstract: The mortality rate in colorectal cancer patients is still high. One of the main consequences of treatment failure is tumor relapse. It is presumed that cancer stem cells (CSCs) are the cause of cancer recurrence and metastasis due to their cellular plasticity. These cells are capable to evade the immune system and endure nutritional deprivation, resulting in CSCs survival after treatment and restoring tumor growth after cancer cell elimination. Thus, precise characterization, successful targeting, and eradication of CSCs can improve cancer treatment.

doctoral thesis   free access