Defining the role of human endogenous retroviruses in pluripotency of colorectal cancer cells

Fatemeh Shokraie

doi:10.18453/rosdok_id00003975

Fatemeh Shokraie

Defining the role of human endogenous retroviruses in pluripotency of colorectal cancer cells

Universität Rostock, 2021

https://doi.org/10.18453/rosdok_id00003975

Abstract: The mortality rate in colorectal cancer patients is still high. One of the main consequences of treatment failure is tumor relapse. It is presumed that cancer stem cells (CSCs) are the cause of cancer recurrence and metastasis due to their cellular plasticity. These cells are capable to evade the immune system and endure nutritional deprivation, resulting in CSCs survival after treatment and restoring tumor growth after cancer cell elimination. Thus, precise characterization, successful targeting, and eradication of CSCs can improve cancer treatment.

Dissertation Freier Zugang

Titel:

Defining the role of human endogenous retroviruses in pluripotency of colorectal cancer cells

Beteiligte Personen:

Fatemeh Shokraie[VerfasserIn]
	1269907042
Dietmar Zechner[AkademischeR BetreuerIn]
	0000-0002-2075-7540
	1103836145
	Rudolf-Zenker-Instituts für Experimentelle Chirurgie, Universitätsmedizin Rostock
Friedrich Prall[AkademischeR BetreuerIn]
	113623496
	Institut für Pathologie, Universitätsmedizin Rostock
Stephan Kersting[AkademischeR BetreuerIn]
	0000-0002-2124-3103
	122324285
	Klinik und Poliklinik für Allgemeine Chirurgie, Universität Greifswald

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universitätsmedizin Rostock[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

The mortality rate in colorectal cancer patients is still high. One of the main consequences of treatment failure is tumor relapse. It is presumed that cancer stem cells (CSCs) are the cause of cancer recurrence and metastasis due to their cellular plasticity. These cells are capable to evade the immune system and endure nutritional deprivation, resulting in CSCs survival after treatment and restoring tumor growth after cancer cell elimination. Thus, precise characterization, successful targeting, and eradication of CSCs can improve cancer treatment. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

570 Biowissenschaften, Biologie

610 Medizin, Gesundheit

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock

2021