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Anna Katharina Frey

Synthesis of small molecules for skin cancer treatment with plasma and non-plasma application

Universität Rostock, 2022

https://doi.org/10.18453/rosdok_id00004037

Abstract: This dissertation deals with the synthesis of small molecules for use in skin cancers with possible plasma application. First, N-glycosylated oxindoles and N-glycosylated isatins bearing electron-withdrawing substituents were synthesized. Furthermore, highly functionalized synthetic building blocks were synthesized in regio- and chemo selective palladium-catalyzed coupling reactions with various boronic acids and alkynes, which then reacted to form heterocycles by acid-mediated cycloisomerization or alkyne-carbonyl metathesis.

doctoral thesis   free access