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Marian Blanco Ponce

Synthesis of polycyclic heteroaromatic hydrocarbons by Pd-catalyzed cross-coupling reactions, alkyne carbonyl metathesis and acid mediated cycloisomerization

Universität Rostock, 2021

Abstract: The present work deals with the synthesis of polycyclic heteroaromatic hydrocarbons based on functionalization of halogenated pyridine derivatives. Various pyrrolo[1,2-a][1,6]naphthyridines, (benzo-)thieno[3,2-f]quinoline , (benzo-)thieno[3,2-f]isoquinoline and 5- and 6-azaindoles were successfully developed based on sequential site- and regioselective Pd-catalyzed C–C and C–N coupling reactions, alkyne carbonyl metathesis and Brønsted acid mediated cycloisomerization. Selected synthesized final products were studied using UV and fluorescence spectroscopy to determine the optical properties.

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