Universität Rostock, 2022
Abstract: This dissertation investigates the effects of platelet-derived growth factors on human primary cells in vitro. In particular, the mesenchymal stem cells of the adipose tissue and the endothelial cells are considered. The effects of the addition of platelet-derived growth factors and TGF-β 1 in particular will be investigated not only morphologically, but also with regard to cell proliferation, metabolic activity, apoptosis, cell cycle and the release of cytokines and chemokines. This is done with regard to the importance of these aspects in the context of wound healing.
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