Hydrogen / deuterium exchange reactions : small variations for heavy changes

Florian Marwan Bourriquen

doi:10.18453/rosdok_id00004295

Florian Marwan Bourriquen

Hydrogen / deuterium exchange reactions : small variations for heavy changes

Universität Rostock, 2022

https://doi.org/10.18453/rosdok_id00004295

Abstract: This dissertation reports the development of new catalytic methodologies for deuterium incorporation into organic molecules. In a first part, the use of a simple Lewis acid is reported for the isotopic labelling of electron-rich (hetero)arenes. Next, two heterogeneous catalysts are presented for the labelling of comparable compounds: a first-generation iron-based system and a follow-up work using manganese. Both materials are easily prepared and fully characterised. Additionally, investigations were performed to gain insight on the mechanisms.

Dissertation Freier Zugang

Titel:

Hydrogen / deuterium exchange reactions: small variations for heavy changes

Beteiligte Personen:

Florian Marwan Bourriquen[VerfasserIn]
	0000-0002-3895-7321
	1289642907
Matthias Beller[AkademischeR BetreuerIn]
	0000-0001-5709-0965
	112081908
	Leibniz-Institut für Katalyse e.V.
Manuel Gemmeren , van[AkademischeR BetreuerIn]
	0000-0003-3080-3579
	1063391156

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

This dissertation reports the development of new catalytic methodologies for deuterium incorporation into organic molecules. In a first part, the use of a simple Lewis acid is reported for the isotopic labelling of electron-rich (hetero)arenes. Next, two heterogeneous catalysts are presented for the labelling of comparable compounds: a first-generation iron-based system and a follow-up work using manganese. Both materials are easily prepared and fully characterised. Additionally, investigations were performed to gain insight on the mechanisms. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

540 Chemie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2022