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Charakterisierung wirkstoffinduzierter Genexpressionsmodulationen bei SYK-, BET- und Kombinationsinhibition in Zelllinien hämatologischer B-Zell-Neoplasien

Universität Rostock, 2022

Abstract: The Spleen Tyrosin Kinase (SYK) and Bromodomain and Extra-Terminal motif (BET) proteins represent promising therapeutic targets for targeted therapies. The combined inhibition of SYK and BET induced synergistic anti-proliferative effects in human and canine neoplasias. Whole-transcriptome analyses showed an enhanced gene expression and a combination-specific gene signature. Gene Ontology Enrichment analyses showed, that primarily cell biologic processes such as DNA replication and cell division were modulated by the combination.

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