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Wentao Xie

Distress analysis of mice used for translational research : reflection of a surgeon on animal welfare

Universität Rostock, 2022

https://doi.org/10.18453/rosdok_id00004344

Abstract: The assessment and improvement of animal welfare is not only an ethical requirement, but also a guarantee of efficient and high quality translational research. In recent years, sophisticated animal models were created to study human diseases. However, the assessment of distress in these animal models is scarce. In order to provide a solid basis for optimizing animal welfare in future studies, body weight, burrowing, nesting activity, faecal corticosterone metabolites (FCMs), and distress scores were analyzed in several animal models.

doctoral thesis   free access