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Svenja Hannah Offer

Cellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosols

Universität Rostock, 2023

https://doi.org/10.18453/rosdok_id00004409

Abstract: This dissertation addresses the question about the toxicological impacts of atmospherically aged biogenic and anthropogenic emissions. In simulation experiments, an anthropogenic (naphthalene) or biogenic (β-pinene) VOC precursor was aged together with a primary aerosol and comprehensively physical and chemical characterized. Using different in vitro airway model systems [BEAS-2B, A549 and a coculture of A549/EA.hy926] in an automated air-liquid interface exposure system, the cellular effects triggered by the aerosols were tested by evaluating the genomic, metabolomic and functional changes.

doctoral thesis   free access