Cellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosols

Svenja Hannah Offer

doi:10.18453/rosdok_id00004409

Svenja Hannah Offer

Cellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosols

Universität Rostock, 2023

https://doi.org/10.18453/rosdok_id00004409

Abstract: This dissertation addresses the question about the toxicological impacts of atmospherically aged biogenic and anthropogenic emissions. In simulation experiments, an anthropogenic (naphthalene) or biogenic (β-pinene) VOC precursor was aged together with a primary aerosol and comprehensively physical and chemical characterized. Using different in vitro airway model systems [BEAS-2B, A549 and a coculture of A549/EA.hy926] in an automated air-liquid interface exposure system, the cellular effects triggered by the aerosols were tested by evaluating the genomic, metabolomic and functional changes.

Dissertation Freier Zugang

Titel:

Cellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosols

Beteiligte Personen:

Svenja Hannah Offer[VerfasserIn]
	1300025026
Ralf Zimmermann[AkademischeR BetreuerIn]
	143922025
	Institut für Chemie, Universität Rostock
Barbara Rothen-Rutishauser[AkademischeR BetreuerIn]
	Adolphe Merkle Institut, Universität Fribourg, Schweiz

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

This dissertation addresses the question about the toxicological impacts of atmospherically aged biogenic and anthropogenic emissions. In simulation experiments, an anthropogenic (naphthalene) or biogenic (β-pinene) VOC precursor was aged together with a primary aerosol and comprehensively physical and chemical characterized. Using different in vitro airway model systems [BEAS-2B, A549 and a coculture of A549/EA.hy926] in an automated air-liquid interface exposure system, the cellular effects triggered by the aerosols were tested by evaluating the genomic, metabolomic and functional changes. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

500 Naturwissenschaften

540 Chemie

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock