| title: |
| Elucidation of molecular recognition structures of peptides and proteins to antibodies
and DNA aptamers by biosensor- mass spectrometry combination |
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| contributing persons: |
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| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
 |
38329-6 |
| Universitätsmedizin Rostock[Grad-verleihende Institution] |
|
1029510660 |
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| abstract: |
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The PROTEX-SPR-MS method has unveiled several epitopes with promising medical applications,
including an epitope peptide suitable for antibody removal in Fabry's disease. Additionally,
an epitope conducive to early heart muscle injury diagnosis was identified and characterized.Furthermore,
PROTEX-SPR-MS has been employed to study two distinct single-stranded DNA aptamers
interacting with a tumor biomarker protein. This analysis has revealed that aptamers
have remarkably similar affinity and epitope binding to antibodies, suggesting their
potential utility in medical applications.
[English] |
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| document type: |
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| institution: |
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| language: |
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publication /
production: |
Rostock
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Rostock: Universität Rostock
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2022
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| statement of responsibility: |
| vorgelegt von Loredana-Mirela Lupu |
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| notes: |
| Enthält Zeitschriftenartikel |
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| identifiers: |
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| access condition: |
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| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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| RosDok id: |
rosdok_disshab_0000003068 |
| created / modified: |
08.11.2023 / 09.11.2023
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| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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