| title: |
| Phosphoproteome analysis of the near-haploid cell line HAP1 reveals phosphorylation
events originating from PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) |
|
| contributing persons: |
| Hasan Albony[VerfasserIn] |
 |
127448958X |
| Hans-Jürgen Thiesen[AkademischeR BetreuerIn] |
|
136714013 |
|
Institut für Immunologie, Universität Rostock |
| Christopher Gerner[AkademischeR BetreuerIn] |
|
Fakultät für Chemie, Universität Wien |
| Hugo Istvan Murua Escobar[AkademischeR BetreuerIn] |
|
12980455X |
|
| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
|
38329-6 |
| Universitätsmedizin Rostock[Grad-verleihende Institution] |
|
1029510660 |
|
| |
| abstract: |
|
PBK is a serine/threonine kinase. During mitosis, PBK phosphorylates the inter-zinc
finger linker sequence (TGEKP) of hundreds of C2H2 zinc finger proteins and liberates
these transcription factors from the condensing chromatin. This study aimed to investigate
PBK-dependent phosphorylation events by analyzing the phosphoproteome of both wild
and PBK knockout HAP1 cells. The analysis identified candidates belong to DNA- and
RNA binding proteins (ADNP and FUBP1) or dynamic regulators of cell organelles (MARCKS
and PGRMC1).
[English] |
|
| document type: |
|
| institution: |
|
| language: |
|
| subject class (DDC): |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2021
|
|
| statement of responsibility: |
| vorgelegt von Hasan Albony |
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000003084 |
| created / modified: |
06.12.2023 / 07.12.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
access
viewer
fulltext