| title: |
| Phosphoproteome analysis of the near-haploid cell line HAP1 reveals phosphorylation
events originating from PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) |
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| contributing persons: |
| Hasan Albony[VerfasserIn] |
 |
127448958X |
| Hans-Jürgen Thiesen[AkademischeR BetreuerIn] |
|
136714013 |
|
Institut für Immunologie, Universität Rostock |
| Christopher Gerner[AkademischeR BetreuerIn] |
|
Fakultät für Chemie, Universität Wien |
| Hugo Istvan Murua Escobar[AkademischeR BetreuerIn] |
|
12980455X |
|
| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
|
38329-6 |
| Universitätsmedizin Rostock[Grad-verleihende Institution] |
|
1029510660 |
|
| |
| abstract: |
|
PBK is a serine/threonine kinase. During mitosis, PBK phosphorylates the inter-zinc
finger linker sequence (TGEKP) of hundreds of C2H2 zinc finger proteins and liberates
these transcription factors from the condensing chromatin. This study aimed to investigate
PBK-dependent phosphorylation events by analyzing the phosphoproteome of both wild
and PBK knockout HAP1 cells. The analysis identified candidates belong to DNA- and
RNA binding proteins (ADNP and FUBP1) or dynamic regulators of cell organelles (MARCKS
and PGRMC1).
[English] |
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| document type: |
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| subject class (DDC): |
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publication /
production: |
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Rostock: Universität Rostock
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|
2021
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| statement of responsibility: |
| vorgelegt von Hasan Albony |
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| identifiers: |
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| access condition: |
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| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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| RosDok id: |
rosdok_disshab_0000003084 |
| created / modified: |
06.12.2023 / 07.12.2023
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| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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