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	0000-0002-2829-8254
	1315138387

Salem Oduro Beffi Sueto

Microarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interaction

Universität Rostock, 2023

https://doi.org/10.18453/rosdok_id00004514

Abstract: The present work uses transcriptomics data from the microarray platform to study the biological imprint of Hutchinson-Gilford progeria syndrome and other senescence processes such as telomere elongation. Literature review of drug repurposing analysis was conducted to find tools that use transcriptomics data as input. RNA-seq technology was used to simultaneously study the gene expression of both the host (human) and the pathogen (S. pyogenes and Influenza A virus). The host expression was used as input for drug repurposing analysis to identify potential drugs for anti-infective treatment.

doctoral thesis   free access