Method improvements for real-time mass spectrometric monitoring of exhaled VOCs in the clinical environment

Giovanni Pugliese

doi:10.18453/rosdok_id00004596

Giovanni Pugliese

Method improvements for real-time mass spectrometric monitoring of exhaled VOCs in the clinical environment

Universität Rostock, 2020

https://doi.org/10.18453/rosdok_id00004596

Abstract: We improved the measurement capabilities of PTR-MS for real-time monitoring of breath VOCs in the clinical environment. In the first study, we evaluated the effects of a modular ion-funnel onto PTR-MS performances in terms of sensitivity and LODs. In the second study we optimized instrumental conditions for direct breath-resolved real-time monitoring of highly reactive compounds. In the third study, we evaluated the effects of potential confounders from the clinical environment such as elevated inspired O2 concentrations onto PTR-MS based VOC analysis.

Dissertation Freier Zugang

Titel:

Method improvements for real-time mass spectrometric monitoring of exhaled VOCs in the clinical environment

Beteiligte Personen:

Giovanni Pugliese[VerfasserIn]
	0000-0002-2869-3588
	1238484441
Jochen Schubert[AkademischeR BetreuerIn]
	0000-0002-0956-9506
	128392088
Dagmar-Christiane Fischer[AkademischeR BetreuerIn]
	113273525
	Universitätsmedizin Rostock, Klinik und Poliklinik Kinder- und Jugendmedizin
Christopher Anthony Mayhew[AkademischeR BetreuerIn]
	Leopold-Franzens-Universität Innsbruck, Institut für Atemgasanalytik

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universitätsmedizin Rostock[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

We improved the measurement capabilities of PTR-MS for real-time monitoring of breath VOCs in the clinical environment. In the first study, we evaluated the effects of a modular ion-funnel onto PTR-MS performances in terms of sensitivity and LODs. In the second study we optimized instrumental conditions for direct breath-resolved real-time monitoring of highly reactive compounds. In the third study, we evaluated the effects of potential confounders from the clinical environment such as elevated inspired O2 concentrations onto PTR-MS based VOC analysis. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

500 Naturwissenschaften

540 Chemie

610 Medizin, Gesundheit

Umfang:

1 Online-Ressource (verschiedene Seitenzählungen)

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2020

Verantwortlichkeitsangabe:

presented by Giovanni Pugliese

Anmerkungen:

Enthält Zeitschriftenbeiträge

Zeitschriftennachweis: 1) Effects of modular ion-funnel technology onto analysis of breath VOCs by means of real-time mass spectrometry. Pugliese Giovanni, Piel Felix, Trefz Phillip, Sulzer Philipp, Schubert Jochen Klaus, Miekisch Wolfram. Analytical Bioanalytical Chemistry 2020; 412, 7131–7140. ISSN:1618-2650. DOI: https://doi.org/10.1007/s00216-020-02846-8. 2) Extending PTR based breath analysis to real-time monitoring of reactive volatile organic compounds. Pugliese Giovanni, Trefz Phillip, Brock Beate, Schubert Jochen Klaus, Miekisch Wolfram. Analyst 2019; 144, 7359–7367. ISSN: 1364-5528. DOI: https://doi.org/10.1039/C9AN01478K. 3) Effects of elevated oxygen levels on VOC analysis by means of PTR-ToF-MS. Trefz Phillip, Pugliese Giovanni, Brock Beate, Schubert Jochen Klaus, Miekisch Wolfram. Journal of Breath Research 2019; 13(4):046004. ISSN: 1752-7163. DOI: 10.1088/1752-7163/ab28ec

Identifikatoren: