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Nooshin Mohebali

Protective role of gut commensal bacteria on epithelial barrier disruption and Ulcerative Colitis in vitro and in vivo

Universität Rostock, 2023

https://doi.org/10.18453/rosdok_id00004620

Abstract: This study investigates the role of three commensal bacteria - Faecalibacterium prausnitzii, Bacteroides faecis, and Roseburia intestinalis - in maintaining intestinal barrier integrity and their potential to mitigate chronic inflammation, with a focus on Ulcerative Colitis (UC). Using in vitro and in vivo models, the study demonstrates that these bacteria alleviate inflammatory-induced impairment of the intestinal barrier, enhance barrier function, and mitigate pro-inflammatory processes.

Dissertation   Freier Zugang