Strategies to control mouse populations : production of species-specific contraceptive peptides in plants as oral vaccine

Khadijeh Ghasemian

doi:10.18453/rosdok_id00004672

Khadijeh Ghasemian

Strategies to control mouse populations : production of species-specific contraceptive peptides in plants as oral vaccine

Universität Rostock, 2023

https://doi.org/10.18453/rosdok_id00004672

Abstract: The aim of the study was to develop strategies to produce an oral contraceptive vaccine for mice in plants, in order to reduce the mouse population. The results showed that mouse-specific contraceptive peptides were successfully produced in plants. All peptides induced IgG antibodies in subcutaneously vaccinated mice. Moreover, oral delivery of the leaves expressing a fusion protein elicited systemic and mucosal cross-reactive antibodies. Observations suggest that plant-produced contraceptives have the potential to be used in the development of feeding baits to reduce the fertility of mice.

Dissertation Freier Zugang

Titel:

Strategies to control mouse populations: production of species-specific contraceptive peptides in plants as oral vaccine

Beteiligte Personen:

Khadijeh Ghasemian[VerfasserIn]
	1341425274
Inge Broer[AkademischeR BetreuerIn]
	139044809
	AUF, Agrobiotechnologie
Julian Ma[AkademischeR BetreuerIn]
	Georges University of London, Institute for Infection and Immunity
Dirk Prüfer[AkademischeR BetreuerIn]
	172624924
	Westfälische Wilhelms-Universität Münster, Institut für Biologie und Biotechnologie der Pflanzen
Eva Stöger[AkademischeR BetreuerIn]
	0000-0002-7651-7992
	1024639649
	Universität für Bodenkultur Wien (BOKU), Department für Angewandte Genetik und Zellbiologie, Institut für Pflanzenbiotechnologie und Zellbiologie

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universität Rostock. Agrar- und Umweltwissenschaftliche Fakultät[Grad-verleihende Institution]
	10025954-6

Zusammenfassung:

The aim of the study was to develop strategies to produce an oral contraceptive vaccine for mice in plants, in order to reduce the mouse population. The results showed that mouse-specific contraceptive peptides were successfully produced in plants. All peptides induced IgG antibodies in subcutaneously vaccinated mice. Moreover, oral delivery of the leaves expressing a fusion protein elicited systemic and mucosal cross-reactive antibodies. Observations suggest that plant-produced contraceptives have the potential to be used in the development of feeding baits to reduce the fertility of mice. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Fakultät für Agrar, Bau und Umwelt

Sprache:

Englisch

Sachgruppe der DNB:

580 Pflanzen (Botanik)

630 Landwirtschaft, Veterinärmedizin

Umfang:

1 Online-Ressource (v, 107 Seiten)

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