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Khadijeh Ghasemian

Strategies to control mouse populations : production of species-specific contraceptive peptides in plants as oral vaccine

Universität Rostock, 2023

https://doi.org/10.18453/rosdok_id00004672

Abstract: The aim of the study was to develop strategies to produce an oral contraceptive vaccine for mice in plants, in order to reduce the mouse population. The results showed that mouse-specific contraceptive peptides were successfully produced in plants. All peptides induced IgG antibodies in subcutaneously vaccinated mice. Moreover, oral delivery of the leaves expressing a fusion protein elicited systemic and mucosal cross-reactive antibodies. Observations suggest that plant-produced contraceptives have the potential to be used in the development of feeding baits to reduce the fertility of mice.

doctoral thesis   free access