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Leonard Andreas Wolfgang Netz

Experimentelle Studien zur Störung der Darmbarriere bei cholestatischer Lebererkrankung

Universität Rostock, September 2023

https://doi.org/10.18453/rosdok_id00004721

Abstract: The intestinal barrier is crucial for protection against pathogens and nutrient absorption. Liver cirrhosis compromises this barrier. This study investigated the intestinal barrier in chronic liver damage using mice with bile duct ligation (BDL). BDL resulted in weight loss, liver damage, and increased paracellular permeability in the intestine. Ghrelin therapy potentially reduced colon permeability. Gene expression analyses following ghrelin therapy showed alterations in TJ proteins. Ghrelin had no impact on weight loss post-BDL.

doctoral thesis   free access