Evaluating in vitro toxicity of flavors in alternative nicotine delivery systems utilizing different in vitro testing strategies

Selina Rinaldi

doi:10.18453/rosdok_id00004874

Selina Rinaldi

Evaluating in vitro toxicity of flavors in alternative nicotine delivery systems utilizing different in vitro testing strategies

Universität Rostock, 2025

https://doi.org/10.18453/rosdok_id00004874

Abstract: The respiratory and local health effects of flavors in alternative nicotine delivery systems (ANDS) are not well understood. This dissertation aimed to develop an in vitro risk assessment strategy for ANDS flavors and identify oral nicotine pouch (ONP) ingredients. Further, the impinger method was optimized for collecting flavored aerosols. Based on the results, a tiered testing approach is advised using submerged and Air-Liquid Interface cell models. Further, standardized testing guidelines for flavoring compounds in emerging ANDS are needed for comprehensive safety assessments.

Dissertation Freier Zugang

Titel:

Evaluating in vitro toxicity of flavors in alternative nicotine delivery systems utilizing different in vitro testing strategies

Beteiligte Personen:

Selina Rinaldi[VerfasserIn]
	1371837376
Ralf Zimmermann[AkademischeR BetreuerIn]
	143922025
	University of Rostock, Institute of Chemistry
Tanja Schwerdtle[AkademischeR BetreuerIn]
	0000-0002-4873-7488
	128451335
	Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universität Rostock. Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

The respiratory and local health effects of flavors in alternative nicotine delivery systems (ANDS) are not well understood. This dissertation aimed to develop an in vitro risk assessment strategy for ANDS flavors and identify oral nicotine pouch (ONP) ingredients. Further, the impinger method was optimized for collecting flavored aerosols. Based on the results, a tiered testing approach is advised using submerged and Air-Liquid Interface cell models. Further, standardized testing guidelines for flavoring compounds in emerging ANDS are needed for comprehensive safety assessments. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

500 Naturwissenschaften

540 Chemie

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock