Establishing the greenhouse-production of FGF21-Transferrin in tobacco seeds and leaves for oral treatment of non-alcoholic steatosis hepatis NASH

Hsuan-Wu Hou

doi:10.18453/rosdok_id00004889

Hsuan-Wu Hou

Establishing the greenhouse-production of FGF21-Transferrin in tobacco seeds and leaves for oral treatment of non-alcoholic steatosis hepatis NASH

Universität Rostock, 2024

https://doi.org/10.18453/rosdok_id00004889

Abstract: Thesis focuses on the production of a variant of the human fibroblast growth factor (FGF21) in plants. This factor is supposed to support the liver function, but has a negative impact on other organs. Hence it has to be directed directly to the liver and should be unstable to avoid its presence in other organs. An oral intake would be preferred. Plants provide an excellent platform for the production of orally applied pharmaceuticals since the cell wall protects the substance from premature degradation in the gastric system.

Dissertation Freier Zugang

Titel:

Establishing the greenhouse-production of FGF21-Transferrin in tobacco seeds and leaves for oral treatment of non-alcoholic steatosis hepatis NASH

Weitere Titel:

Etablierung der Gewächshausproduktion von FGF21-Transferrin in Tabaksamen und -blättern zur oralen Behandlung der nichtalkoholische Steatohepatitis NASH [übersetzt]

Beteiligte Personen:

Hsuan-Wu Hou[VerfasserIn]
	137268090X
Henrik Nausch[AkademischeR BetreuerIn]
	0000-0001-5393-3267
	1030025401
	Fraunhofer-Institut für Molekularbiologie und Angewandte Ökologie IME, Abt. Bioprozessentwicklung
Inge Broer[AkademischeR BetreuerIn]
	139044809
	Universität Rostock, AUF, Agrobiotechnologie
Susanne Klaus[AkademischeR BetreuerIn]
	0000-0001-8726-185X
	173758878
	Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE), Abt. Physiologie des Energiestoffwechsels
Rima Menassa[AkademischeR BetreuerIn]
	University of Western Ontario, Biology Department / London Research and Development Centre, Agriculture and Agri-Food Canada

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universität Rostock. Agrar- und Umweltwissenschaftliche Fakultät[Grad-verleihende Institution]
	10025954-6

Zusammenfassung:

Thesis focuses on the production of a variant of the human fibroblast growth factor (FGF21) in plants. This factor is supposed to support the liver function, but has a negative impact on other organs. Hence it has to be directed directly to the liver and should be unstable to avoid its presence in other organs. An oral intake would be preferred. Plants provide an excellent platform for the production of orally applied pharmaceuticals since the cell wall protects the substance from premature degradation in the gastric system. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Fakultät für Agrar, Bau und Umwelt

Sprache:

Englisch

Sachgruppe der DNB:

580 Pflanzen (Botanik)

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock

2024

Verantwortlichkeitsangabe: