Generation and characterization of ultrafine particles in laboratory studies and their mass deposition at the air-liquid interface

Anusmita Das

doi:10.18453/rosdok_id00004910

Anusmita Das

Generation and characterization of ultrafine particles in laboratory studies and their mass deposition at the air-liquid interface

Universität Rostock, 2025

https://doi.org/10.18453/rosdok_id00004910

Abstract: Ultrafine particles (UFPs, ≤100 nm) contribute to air pollution's health impacts, but their toxicity drivers are unclear. This study generated soot UFPs with similar cores but varying chemical loads (e.g., PAHs) and tested them on A549 cells in ALI systems. Higher PAH content increased xenobiotic metabolism, showing chemical composition's role. Soot and copper UFPs, matched physically, revealed higher-than-predicted mass deposition in ALI systems, highlighting model limitations. The method enables precise UFP property control, advancing reproducible toxicity assessments.

Dissertation Freier Zugang

Titel:

Generation and characterization of ultrafine particles in laboratory studies and their mass deposition at the air-liquid interface

Beteiligte Personen:

Anusmita Das[VerfasserIn]
	0009-0002-2217-7555
	137587053X
Ralf Zimmermann[AkademischeR BetreuerIn]
	143922025
	University of Rostock, Institute of Chemistry
Konstantinos Eleftheriadis[AkademischeR BetreuerIn]
	0000-0003-2265-4905
	1322449414
	Ethniko Kentro Ereunas Physikon Epistemon Demokritos, Athens, GR

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universität Rostock. Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

Ultrafine particles (UFPs, ≤100 nm) contribute to air pollution's health impacts, but their toxicity drivers are unclear. This study generated soot UFPs with similar cores but varying chemical loads (e.g., PAHs) and tested them on A549 cells in ALI systems. Higher PAH content increased xenobiotic metabolism, showing chemical composition's role. Soot and copper UFPs, matched physically, revealed higher-than-predicted mass deposition in ALI systems, highlighting model limitations. The method enables precise UFP property control, advancing reproducible toxicity assessments. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

500 Naturwissenschaften

540 Chemie

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock

2025