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Zezhong Song

Gender-specific impact of direct-coupled alternating electric fields on human chondrocytes

Universität Rostock, June 2024

https://doi.org/10.18453/rosdok_id00005205

Abstract: In cell-based therapy for cartilage repair, preventing fibrocartilage formation due to dedifferentiation is crucial. This study examined how alternating electric fields affect the redifferentiation of human chondrocytes from male and female donors. Stimulation at 15–20 V/m increased the Col2/Col1 ratio and promoted rounded morphology, indicating enhanced redifferentiation. Meanwhile, female chondrocytes showed more collagen 1 production and fibroblast-like shape. These results suggest male chondrocytes showed higher tendency towards redifferentiation in response to electrical stimulation.

doctoral thesis   free access