Gender-specific impact of direct-coupled alternating electric fields on human chondrocytes

Zezhong Song

doi:10.18453/rosdok_id00005205

Zezhong Song

Gender-specific impact of direct-coupled alternating electric fields on human chondrocytes

Universität Rostock, June 2024

https://doi.org/10.18453/rosdok_id00005205

Abstract: In cell-based therapy for cartilage repair, preventing fibrocartilage formation due to dedifferentiation is crucial. This study examined how alternating electric fields affect the redifferentiation of human chondrocytes from male and female donors. Stimulation at 15–20 V/m increased the Col2/Col1 ratio and promoted rounded morphology, indicating enhanced redifferentiation. Meanwhile, female chondrocytes showed more collagen 1 production and fibroblast-like shape. These results suggest male chondrocytes showed higher tendency towards redifferentiation in response to electrical stimulation.

Dissertation Freier Zugang

Titel:

Gender-specific impact of direct-coupled alternating electric fields on human chondrocytes

Beteiligte Personen:

Zezhong Song[VerfasserIn]
	1393423531
Rainer Bader[AkademischeR BetreuerIn]
	133499847
	Forschungslabor für Biomechanik und Implantattechnologie, Universität Rostock
Jessica Bertrand[AkademischeR BetreuerIn]
	0000-0001-9511-4999
	133835413
	Orthopädische Universitätsklinik mit Endoprothetikzentrum, Universitätsklinikum Magdeburg
Kirsten Peters[AkademischeR BetreuerIn]
	0000-0003-0254-176X
	17300136X
	Center for Medical Research (ZEMFO), Institute of Cell Biology, Universität Rostock

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universitätsmedizin Rostock[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

In cell-based therapy for cartilage repair, preventing fibrocartilage formation due to dedifferentiation is crucial. This study examined how alternating electric fields affect the redifferentiation of human chondrocytes from male and female donors. Stimulation at 15–20 V/m increased the Col2/Col1 ratio and promoted rounded morphology, indicating enhanced redifferentiation. Meanwhile, female chondrocytes showed more collagen 1 production and fibroblast-like shape. These results suggest male chondrocytes showed higher tendency towards redifferentiation in response to electrical stimulation. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

570 Biowissenschaften, Biologie

610 Medizin, Gesundheit

Umfang:

1 Online-Ressource (V, 87 Seiten)

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