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	1412077737

Prabir Dhar

E2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanoma

Universität Rostock, April 2025

https://doi.org/10.18453/rosdok_id00005667

Abstract: In melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome.

doctoral thesis   free access