E2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanoma

Prabir Dhar

doi:10.18453/rosdok_id00005667

Prabir Dhar

E2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanoma

Universität Rostock, April 2025

https://doi.org/10.18453/rosdok_id00005667

Abstract: In melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome.

Dissertation Freier Zugang

Titel:

E2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanoma

Beteiligte Personen:

Prabir Dhar[VerfasserIn]
	1412077737
Stefanie Scheu[AkademischeR BetreuerIn]
	0000-0002-9707-8191
	1213679125
	Universitätsmedizin Rostock, Institut für Immunologie
Hugo Istvan Murua Escobar[AkademischeR BetreuerIn]
	12980455X
Josef Mautner[AkademischeR BetreuerIn]
	Helmholtz Zentrum München, Institut für Virologie

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universitätsmedizin Rostock[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

In melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

570 Biowissenschaften, Biologie

610 Medizin, Gesundheit

Umfang:

1 Online-Ressource (IV, 86 Seiten)

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