| title: |
| Metabolic alterations and early development of sarcopenia in a murine model of cholestatic
liver disease |
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| contributing persons: |
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| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
 |
38329-6 |
| Universitätsmedizin Rostock[Grad-verleihende Institution] |
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1029510660 |
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| abstract: |
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A murine bile duct ligation (BDL) model was used to study molecular mechanisms of
sarcopenia and malnutrition in cholestatic liver disease. C57BL/6J mice randomly underwent
a BDL or Sham surgery or were used as controls. Metabolism, inflammatory markers,
fractional protein synthesis rate, muscle function and gene expression were assessed.
Sarcopenia occurs early, and involves systemic inflammation, a catabolic state, reduced
protein synthesis and degradation of muscle proteins. Malnutrition and sarcopenia
are present in parallel in, and that they trigger each other in a sort of vicious
circle.
[English] |
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| document type: |
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| institution: |
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| language: |
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| subject class (DDC): |
| 610 Medical sciences Medicine |
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| extent: |
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1 Online-Ressource (96, xvii Seiten)
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publication /
production: |
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Rostock: Universität Rostock
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2025
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| statement of responsibility: |
| vorgelegt von Ottavia Agrifoglio |
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| identifiers: |
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| access condition: |
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| license/rights statement: |
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| RosDok id: |
rosdok_disshab_0000003633 |
| created / modified: |
13.08.2026 / 13.08.2026
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| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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