Cytocompatibility and biocompatibility approaches with analysis of the in vivo immune responses of collagen-based and synthetic materials for bone regeneration

Yanru Ren

doi:10.18453/rosdok_id00005766

Yanru Ren

Cytocompatibility and biocompatibility approaches with analysis of the in vivo immune responses of collagen-based and synthetic materials for bone regeneration

Universität Rostock, 13.03.2025

https://doi.org/10.18453/rosdok_id00005766

Abstract: This study aims to clarify the immunomodulatory role of these biomaterials in relation to tissue regeneration. Evaluate the cellular and biocompatibility properties of synthetic bone substitutes with metal ions and collagen-based barrier membranes. Assessments used subcutaneous or calvarial implantation models, focusing on macrophage-driven inflammatory patterns and tissue regeneration. Aligned with 3R principles, it also investigates jellyfish collagen to optimize in vitro cell culture and improve the accuracy of cellular compatibility predictions.

Dissertation Freier Zugang

Titel:

Cytocompatibility and biocompatibility approaches with analysis of the in vivo immune responses of collagen-based and synthetic materials for bone regeneration

Beteiligte Personen:

Yanru Ren[VerfasserIn]
	1416949909
Volker Alt[AkademischeR BetreuerIn]
	123694574
	Universitätsklinikum Regensburg, Klinik und Poliklinik für Unfallchirurgie
Mike Barbeck[AkademischeR BetreuerIn]
	0000-0002-3001-1347
	1080680519
	Universitätsmedizin Rostock, Klinik und Poliklinik für Dermatologie und Venerologie
Michael Dau[AkademischeR BetreuerIn]
	13218916X
	Universitätsmedizin Rostock, Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universitätsmedizin Rostock[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

This study aims to clarify the immunomodulatory role of these biomaterials in relation to tissue regeneration. Evaluate the cellular and biocompatibility properties of synthetic bone substitutes with metal ions and collagen-based barrier membranes. Assessments used subcutaneous or calvarial implantation models, focusing on macrophage-driven inflammatory patterns and tissue regeneration. Aligned with 3R principles, it also investigates jellyfish collagen to optimize in vitro cell culture and improve the accuracy of cellular compatibility predictions. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

610 Medizin, Gesundheit

Umfang:

1 Online-Ressource (131 Seiten)

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock