New cycloadditions and deconjugative alkylations of α,β-unsaturated ketones enabled by transition metal, phosphine and base catalysis

Saikumar Banda

doi:10.18453/rosdok_id00005793

Saikumar Banda

New cycloadditions and deconjugative alkylations of α,β-unsaturated ketones enabled by transition metal, phosphine and base catalysis

Universität Rostock, 2025

https://doi.org/10.18453/rosdok_id00005793

Abstract: This dissertation develops novel catalytic methods for the functionalization of α,β-unsaturated ketones through cycloaddition and deconjugative alkylation reactions using transition-metal, organophosphine, and Brønsted base catalysis. Efficient syntheses of polycyclic and spirocyclic heterocycles were achieved with high selectivity, broad substrate scope, and scalability. Mechanistic studies provided insights into catalyst-controlled reactivity, expanding synthetic strategies for medicinal and materials chemistry.

Dissertation Freier Zugang

Titel:

New cycloadditions and deconjugative alkylations of α,β-unsaturated ketones enabled by transition metal, phosphine and base catalysis

Beteiligte Personen:

Saikumar Banda[VerfasserIn]
	1419535358
Malte Brasholz[AkademischeR BetreuerIn]
	0000-0001-8184-646X
	133977218
	Universität Rostock
Nina Schützenmeister[AkademischeR BetreuerIn]
	0000-0001-9608-0057
	1024523241
	Universität Marburg

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universität Rostock. Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

This dissertation develops novel catalytic methods for the functionalization of α,β-unsaturated ketones through cycloaddition and deconjugative alkylation reactions using transition-metal, organophosphine, and Brønsted base catalysis. Efficient syntheses of polycyclic and spirocyclic heterocycles were achieved with high selectivity, broad substrate scope, and scalability. Mechanistic studies provided insights into catalyst-controlled reactivity, expanding synthetic strategies for medicinal and materials chemistry. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

540 Chemie

Umfang:

1 Online-Ressource (XII, 171 Seiten)

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock