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	1419535358

Saikumar Banda

New cycloadditions and deconjugative alkylations of α,β-unsaturated ketones enabled by transition metal, phosphine and base catalysis

Universität Rostock, 2025

https://doi.org/10.18453/rosdok_id00005793

Abstract: This dissertation develops novel catalytic methods for the functionalization of α,β-unsaturated ketones through cycloaddition and deconjugative alkylation reactions using transition-metal, organophosphine, and Brønsted base catalysis. Efficient syntheses of polycyclic and spirocyclic heterocycles were achieved with high selectivity, broad substrate scope, and scalability. Mechanistic studies provided insights into catalyst-controlled reactivity, expanding synthetic strategies for medicinal and materials chemistry.

doctoral thesis   free access