| title: |
| NAALADL1 as a key modulator of resistance to Tumor Treating Fields therapy in colorectal
cancer |
|
| contributing persons: |
|
| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
 |
38329-6 |
| Universitätsmedizin Rostock[Grad-verleihende Institution] |
|
1029510660 |
|
| |
| abstract: |
|
Colorectal cancer (CRC) shows heterogeneous responses to Tumor Treating Fields (TTF),
a non-invasive therapy disrupting mitosis. In 21 CRC cell lines, TTF induced microtubule
disruption, mitotic defects, metabolic stress, DNA damage, and apoptosis. NAALADL1
was upregulated in resistant cells; its knockdown enhanced TTF sensitivity by stabilizing
microtubules and inducing G2/M arrest. Virtual screening identified Lumacaftor and
Bestatin as synergistic with TTF, highlighting NAALADL1 as a promising target for
personalized CRC therapy.
[English] |
|
| document type: |
|
| institution: |
|
| language: |
|
| subject class (DDC): |
| 570 Life science |
| 610 Medical sciences Medicine |
|
| extent: |
|
1 Online-Ressource (III, 88 Seiten)
|
|
| |
publication /
production: |
|
Rostock: Universität Rostock
|
|
2025
|
|
| statement of responsibility: |
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000003670 |
| created / modified: |
17.09.2026 / 17.09.2026
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
access
viewer
fulltext