Cold plasma-mediated toxicity in cutaneous and ulcerating cancer tissues

Fariba Saadati

doi:10.18453/rosdok_id00005802

Fariba Saadati

Cold plasma-mediated toxicity in cutaneous and ulcerating cancer tissues

Universität Rostock, 2024

https://doi.org/10.18453/rosdok_id00005802

Abstract: Breast cancer mortality and treatment side effects highlight the need for alternative or complementary therapies. Physical plasma has emerged as a promising anticancer approach. This thesis explores plasma’s effects on ulcerating breast cancer using 2D/3D in vitro models, in vivo xenografts, patient-derived tissues, and biopsies. Plasma consistently reduced tumor growth, induced programmed cell death, and modulated the tumor microenvironment. It also triggered systemic immune effects and showed no genotoxicity, supporting its safe and effective complementary therapy.

Dissertation Freier Zugang

Titel:

Cold plasma-mediated toxicity in cutaneous and ulcerating cancer tissues

Beteiligte Personen:

Fariba Saadati[VerfasserIn]
	1419806807
Steffen Emmert[AkademischeR BetreuerIn]
	133299341
	Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsmedizin Rostock
Brigitte Vollmar[AkademischeR BetreuerIn]
	136319564
	Rudolf-Zenker-Institut für Experimentelle Chirurgie, Universitätsmedizin Rostock
Martina Meinke[AkademischeR BetreuerIn]
	0000-0002-3937-9906
	114762627
	Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universitätsmedizin Rostock[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

Breast cancer mortality and treatment side effects highlight the need for alternative or complementary therapies. Physical plasma has emerged as a promising anticancer approach. This thesis explores plasma’s effects on ulcerating breast cancer using 2D/3D in vitro models, in vivo xenografts, patient-derived tissues, and biopsies. Plasma consistently reduced tumor growth, induced programmed cell death, and modulated the tumor microenvironment. It also triggered systemic immune effects and showed no genotoxicity, supporting its safe and effective complementary therapy. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

570 Biowissenschaften, Biologie

590 Tiere (Zoologie)

Umfang:

1 Online-Ressource (verschiedene Seitenzählungen)

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