Universität Rostock, 2009
Abstract: The smooth muscle of rat portal vein shows spontaneous mechanical activity that is triggered by complex action potentials with slow waves and fast spikes. The ionic mechanisms underlying these spikes have not yet been determined and were the object of interest to this study. The results confirmed the physiological role of L-type calcium currents but did also show that known potassium currents insufficiently explain current during repolarization. There is theoretical and experimental evidence to suspect calcium dependent potassium currents to play a key role during this part of the fast spike.
doctoral thesis free access