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Philipp Julian Köster

Biochips for the Detection of Biological Cell Potentials

Universität Rostock, 2010

Abstract: This work shows the applicability of three biochip types with integrated microelectrodes. To differentiate thermal and athermal effects, action potentials (AP) of dielectrophoretically positioned neuronal networks were detected under HF-EMF exposition on the Si-neurochip. AP of nerves and cardiomyocytes were detected with the modular glass chip system MOGS. With the PoreGenic® Patch Clamp system, cardiac AP and transmembrane potentials of fibroblasts were detected; on-chip polymers for cell structuring were examined as well as FIB SEM images used to describe the cell-electrode interaction.

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