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Stephanie Nemati

Effekte der intramyokardialen autologen Transplantation mononukleärer Zellen aus dem Nabelschnurblut in einem neuen Modell zur Induktion einer chronischen rechtsventrikulären Volumenbelastung im Schafmodell

Universität Rostock, 2009

Abstract: We aimed to evaluate the feasibility and efficacy of intramyocardial autologous umbilical cord blood mononuclear cell transplantation on right ventricular (RV) function in a novel model of chronic RV volume overload, including transannular patch augmentation and pulmonary annulus distortion without cardiopulmonary bypass. Our results indicate that surgically induced RV overload constitutes a valid large animal model and conductance-catheter-analyses as well as immunohistological examinations reveal that the chronically volume-overloaded RV profits from stem cell therapy.

doctoral thesis   free access    


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