Universität Rostock, 2011
Abstract: At the onset of pregnancy a new variant of the eIF4E occurs in the endometrium. With a molecular mass about 23 kDa. At the same time the eIF4E repressor protein is hypophosphorylated. The 23 kDa variant lacks the amino acids 1-21 at the N-terminus. It is formed by cleaving of a Ca-dependent protease. This new variant is able to interact well with die Cap-structure of the mRNA, but poorly with the 4E-BP1. It is likely that the small sized variant might overcome translational repression caused by eIF4E-BP1 at the time of implantation to maintain translation of specific proteins.
doctoral thesis free access