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Carsten Tautorat

Konzeption eines Patch-on-Chip-Systems für Wirkstofftests und Grundlagenforschung an vernetzten adhärenten Zellen

Universität Rostock, 2014

Abstract: This thesis reviews the current state of the automated patch-clamp techniques. Up to now, only the conventional (manual) patch-clamp technique allows for signal recordings from adherent cell networks. The thesis presents the concept of a novel system for the automatic patch-clamp analysis of adherent cell networks. To enable whole-cell patchclamp recordings, the system exploits the new technique of local electroporation with microstructured needle electrodes. For electroporation and signal recording, a chip-based setup with software controlled electronics has been developed.

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