Universität Rostock, 2020
Abstract: Wasp venom allergy is one of the main reasons for severe anaphylaxy. Although venom immunotherapy (VIT) is an efficient therapy, its mechanisms at the antigen specific T-cell level are still not completely understood and studies are limited due to their low frequency in the periphery. Here we characterised antigen-specific peripheral T-cell responses during initiation of VIT directly ex vivo by applying the novel flow cytometric antigen-reactive T cell enrichment protocol (ARTE) to analyse small amounts of antigen-specific T cells.
doctoral thesis free access