Exploring the spatio-temporal dynamics of lipid rafts and their role in Signal transduction : a modeling and simulation approach

Fiete Haack

doi:10.18453/rosdok_id00001767

Fiete Haack

Exploring the spatio-temporal dynamics of lipid rafts and their role in Signal transduction : a modeling and simulation approach

Universität Rostock, 2016

https://doi.org/10.18453/rosdok_id00001767

Abstract: The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin signaling is explored by means of an integrated in silico and in vitro approach.

Dissertation Freier Zugang

Titel:

Exploring the spatio-temporal dynamics of lipid rafts and their role in Signal transduction: a modeling and simulation approach

Beteiligte Personen:

Fiete Haack[VerfasserIn]
	1106336216
Adelinde M. Uhrmacher , Prof. Dr. rer. nat. habil.[AkademischeR BetreuerIn]
	136258794
	Univerität Rostock, Institut für Informatik
Kevin Burrage , Prof. Dr.[AkademischeR BetreuerIn]
	QUT, Brisbane, Australia; University of Oxford, UK, Computational Mathematics; Department of Computer Science
Edda Klipp , Prof. Dr. Dr. h.c.[AkademischeR BetreuerIn]
	1018396683
	Humboldt-Universität zu Berlin, Institut für Biologie, Theoretische Biophysik

Beteiligte Körperschaften:

Universität Rostock, Fakultät für Informatik und Elektrotechnik[Grad-verleihende Institution]
	10085032-7

Zusammenfassung:

The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin signaling is explored by means of an integrated in silico and in vitro approach. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Fakultät für Informatik und Elektrotechnik

Sprache:

Englisch

Sachgruppe der DNB:

004 Informatik

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock

2016