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Fiete Haack

Exploring the spatio-temporal dynamics of lipid rafts and their role in Signal transduction:
a modeling and simulation approach

Dissertation, Rostock, 2016
The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin signaling is explored by means of an integrated in silico and in vitro approach.
URL: http://rosdok.uni-rostock.de/resolve/id/rosdok_disshab_0000001588

Dokumente:
Dissertation_Haack_2016.pdf (11,14 MB)

Einrichtung:
Fakultät für Informatik und Elektrotechnik
Gutachter:
Adelinde M. Uhrmacher (Prof. Dr. rer. nat. habil.)
Univerität Rostock, Institut für Informatik
Kevin Burrage (Prof. Dr.)
QUT, Brisbane, Australia; University of Oxford, UK, Computational Mathematics; Department of Computer Science
Edda Klipp (Prof. Dr. Dr. h.c.)
Humboldt-Universität zu Berlin, Institut für Biologie, Theoretische Biophysik
Jahr der Abgabe:
2015
Jahr der Verteidigung:
2016

Schlagworte:
Wnt/beta-catenin signaling
rule-based modelling
cellular automata
reactive oxygen species
neural differentiation
DDC Klassifikation:
006 Spezielle Methoden der Informatik
570 Biowissenschaften; Biologie

URN:
urn:nbn:de:gbv:28-diss2016-0080-1

eingestellt am:
18. Juli 2016
letzte Änderung:
11. August 2016