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Haack,  Fiete

Exploring the spatio-temporal dynamics of lipid rafts and their role in Signal transduction  : a modeling and simulation approach

Rostock : Universität , 2016

https://doi.org/10.18453/rosdok_id00001767

http://purl.uni-rostock.de/rosdok/id00001767

The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin signaling is explored by means of an integrated in silico and in vitro approach.

Dissertation Open Access


Einrichtung :
Fakultät für Informatik und Elektrotechnik
Gutachter :
Uhrmacher,  Adelinde M.  (Prof. Dr. rer. nat. habil.)
Burrage,  Kevin  (Prof. Dr.)
Klipp,  Edda  (Prof. Dr. Dr. h.c.)
Jahr der Abgabe:
2015
Jahr der Verteidigung:
2016
Sprache(n) :
Englisch
Schlagworte:
Wnt/beta-catenin signaling, rule-based modelling, cellular automata, reactive oxygen species, neural differentiation
DDC Klassifikation :
004 Informatik
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2016-0080-1
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001767
erstellt am:
2016-07-18
zuletzt geändert am:
2018-06-30
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