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Fiete Haack

Exploring the spatio-temporal dynamics of lipid rafts and their role in Signal transduction : a modeling and simulation approach

Universität Rostock, 2016

Abstract: The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin signaling is explored by means of an integrated in silico and in vitro approach.

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