| title: |
| Exploring the spatio-temporal dynamics of lipid rafts and their role in Signal transduction:
a modeling and simulation approach |
|
| contributing persons: |
| Fiete Haack[VerfasserIn] |
 |
1106336216 |
| Adelinde M. Uhrmacher
, Prof. Dr. rer. nat. habil.[AkademischeR BetreuerIn] |
|
136258794 |
|
Univerität Rostock, Institut für Informatik |
| Kevin Burrage
, Prof. Dr.[AkademischeR BetreuerIn] |
|
QUT, Brisbane, Australia; University of Oxford, UK, Computational Mathematics; Department
of Computer Science |
| Edda Klipp
, Prof. Dr. Dr. h.c.[AkademischeR BetreuerIn] |
|
1018396683 |
|
Humboldt-Universität zu Berlin, Institut für Biologie, Theoretische Biophysik |
|
| contributing corporate bodies: |
| Universität Rostock, Fakultät für Informatik und Elektrotechnik[Grad-verleihende Institution] |
|
10085032-7 |
|
| |
| abstract: |
|
The aim of this thesis is to elucidate the biological as well as methodological implications
that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the
effect of raft-dependent receptors dynamics on both, individual signaling events as
well as the canonical Wnt signaling pathway, is thoroughly analyzed.
To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata
based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin
signaling is explored by means of an integrated in silico and in vitro approach.
[English] |
|
| document type: |
|
| institution: |
| Faculty of Computer Science and Electrical Engineering |
|
| language: |
|
| subject class (DDC): |
| 004 Data processing Computer sciences |
| 570 Life science |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2016
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000001588 |
| created / modified: |
18.07.2016 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
access
viewer
fulltext