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Satenik Mkrtchyan

Exploration of new sustainable synthetic methods for the synthesis of fused pyridines and 4-quinolones based on the domino reaction of chromones and other masked dielectrophiles with nucleophiles

Universität Rostock, 2015

Abstract: The present work aimed to study the big potential of chromone derivatives and 1-(2-fluorophenyl)prop-2-yn-1-ones for the synthesis of purine-like fused pyridines and 4-quinolone derivatives. In this regard, a wide range of substituents and substitution patterns are tolerated in the reaction. In addition a new and easy way for synthesis of 4-quinolone derivatives and other fused systems via domino cycloaddition reactions of ortho-fluoro substituted benzoylchromones, 1-(2-fluorophenyl)prop-2-yn-1-ones and aliphatic or aromatic amines were developed.

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