MicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patients

Madhan Thamilarasan

doi:10.18453/rosdok_id00001548

Madhan Thamilarasan

MicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patients

Universität Rostock, 2015

https://doi.org/10.18453/rosdok_id00001548

Abstract: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system. There are many types of disease-modifying drugs available but none of them can cure MS. The studies reported in this thesis analyzed the changes which happen at the transcriptome level during the course of treatment with glatiramer acetate (GA) and interferon-beta-1b. The studies reported revealed several differentially expressed transcripts which included both mRNAs and microRNAs. These can be considered as biomarkers for therapy monitoring and help to better understand the mechanisms of action of the drugs.

Dissertation Freier Zugang

Titel:

MicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patients

Beteiligte Personen:

Madhan Thamilarasan[VerfasserIn]
	1071833413
Uwe Zettl , Prof. Dr. med.[AkademischeR BetreuerIn]
	120760819
	University of Rostock, Department of Neurology
Friedemann Paul , Prof. Dr. med.[AkademischeR BetreuerIn]
	Charité, Berlin, NeuroCure Clinical Research Center
Jürgen Faiss , Dr. med.[AkademischeR BetreuerIn]
	Asklepios Klinikum Teupitz, Department of Neurology

Beteiligte Körperschaften:

Universität Rostock, Universitätsmedizin[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system. There are many types of disease-modifying drugs available but none of them can cure MS. The studies reported in this thesis analyzed the changes which happen at the transcriptome level during the course of treatment with glatiramer acetate (GA) and interferon-beta-1b. The studies reported revealed several differentially expressed transcripts which included both mRNAs and microRNAs. These can be considered as biomarkers for therapy monitoring and help to better understand the mechanisms of action of the drugs. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

610 Medizin, Gesundheit

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock