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Franz Joseph Dieckmann

Qualitative und quantitative Analyse der Huntingtin-Aggregatbildung im transgenen Chorea-Huntington-Rattenmodell BACHD TG22

Universität Rostock, 2018

Abstract: Huntington's disease (HD) is a letal inherited neurodegenative disorder. Despite the identification of the responsible gene in 1993, the mechanisms underlying HD pathogenesis are still unkown. A hallmark of HD is the development of unsoluble aggregates of the protein "Huntingtin". This work studies the development of Huntingtin aggregates in the transgene rat line BACHD TG 22. This rat model is the first transgene HD animal model that lacks Huntingtin aggregates dispite typical age-dependent movement disorder.

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