| title: |
| Effect of cannabidiol on disease-associated functions of human vascular smooth muscle
cells: role of the anti-oxidative enzyme heme oxygenase-1 |
|
| contributing persons: |
| Margit Schwartz[VerfasserIn] |
 |
1193142997 |
| Burkhard Hinz[AkademischeR BetreuerIn] |
|
136257240 |
| Bernhard Rauch[AkademischeR BetreuerIn] |
| Karin Kraft[AkademischeR BetreuerIn] |
|
136051855 |
|
| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
|
38329-6 |
| Universitätsmedizin Rostock[Grad-verleihende Institution] |
|
1029510660 |
|
| |
| abstract: |
|
Excessive proliferation and migration of VSMC are closely linked to cardiovascular
diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory
effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1
was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition
of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown
of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and
potential protective effects via an HO-1-independent mechanism.
[English] |
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| document type: |
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| institution: |
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| language: |
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| subject class (DDC): |
| 570 Life science |
| 610 Medical sciences Medicine |
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| |
publication /
production: |
|
Rostock: Universität Rostock
|
|
2018
|
|
| statement of responsibility: |
| vorgelegt von Margit Schwartz |
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| |
| identifiers: |
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| access condition: |
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| license/rights statement: |
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| RosDok id: |
rosdok_disshab_0000002165 |
| created / modified: |
21.08.2019 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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