| title: |
| Characterization and comparison of the angiogenic and cardio-regenerative potential
of mesenchymal CD271+ and hematopoietic CD133+ bone marrow stem cells by means of
in vitro and in vivo angiogenesis models |
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| contributing persons: |
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| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
 |
38329-6 |
| Universitätsmedizin Rostock[Grad-verleihende Institution] |
|
1029510660 |
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| |
| abstract: |
|
This study intends to examine the therapeutic potential of mesenchymal CD271+ stem
cells in comparison to hematopoietic CD133+ cells with regard to their application
in myocardial infarction. At his, in vitro proliferation assays showed that the application
of CD271+ stem cells results in improved angiogenic potential and the combination
of CD133+ and CD271+ cells seems to be the most effective approach. Furthermore, an
in vivo analysis has been performed in a mouse-model with ligation of the left anterior
descendent artery.
[English] |
|
Diese Studie hat das therapeutische Potenzial mesenchymaler CD271+ Stammzellen im
Vergleich zu hämatopoetischen CD133+ Zellen in Hinsicht auf ihre Verwendung bei myokardialer
Ischämie untersucht. Hierbei haben in vitro Proliferations-Assays gezeigt, dass die
Verwendung von CD271+ Stammzellen in verbessertem angiogenetischem Potenzial resultiert
und die Kombination mit CD133+ Zellen der effektivste Ansatz zu sein scheint. Zudem
wurde eine in vivo Analyse durchgeführt mittels Mausmodell mit Ligatur der LAD-Arterie.
[German] |
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| document type: |
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| institution: |
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| language: |
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| subject class (DDC): |
| 500 Natural sciences |
| 610 Medical sciences Medicine |
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| extent: |
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1 Online-Ressource (76, XXXIV Seiten)
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publication /
production: |
Rostock
|
Rostock: Universität Rostock
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|
2020
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|
| statement of responsibility: |
| vorgelegt von Sarah Hélène Sasse |
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| identifiers: |
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| access condition: |
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| license/rights statement: |
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| RosDok id: |
rosdok_disshab_0000003258 |
| created / modified: |
26.05.2025 / 26.05.2025
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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