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Anusmita Das

Generation and characterization of ultrafine particles in laboratory studies and their mass deposition at the air-liquid interface

Universität Rostock, 2025

https://doi.org/10.18453/rosdok_id00004910

Abstract: Ultrafine particles (UFPs, ≤100 nm) contribute to air pollution's health impacts, but their toxicity drivers are unclear. This study generated soot UFPs with similar cores but varying chemical loads (e.g., PAHs) and tested them on A549 cells in ALI systems. Higher PAH content increased xenobiotic metabolism, showing chemical composition's role. Soot and copper UFPs, matched physically, revealed higher-than-predicted mass deposition in ALI systems, highlighting model limitations. The method enables precise UFP property control, advancing reproducible toxicity assessments.

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