| title: |
| Influence of Fcγ receptor distribution on mannose receptor mediated phagocytosis |
|
| contributing persons: |
| Syed Furquan Ahmad[VerfasserIn] |
 |
143082981 |
| Sergei A. Kuznetsov
, PD Dr.[AkademischeR BetreuerIn] |
| Peter Hinterdorfer
, Prof.[AkademischeR BetreuerIn] |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
In this study the recognition maps obtained by the simultaneous topography and recognition
(TREC) imaging revealed that Fcγ receptors are distributed in micro-domains of sizes
4nm to 200nm. The fluorescent and electron-microscopy provided further evidence that
these clusters are located within close proximity of mannose receptors. This pattern
of distribution of FcγRs and MRs led to inhibition of the MR mediated mediated phagocytosis.
The data presented in this thesis provide evidences of cross-talk between FcγR mediated
and MR mediated phagocytosis.
[English] |
|
Die vorliegende Arbeit zeigt mit Hilfe des TREC-Imagings (topography and recognition),
dass Fcγ-Rezeptoren (FcγR) in Mikrodomänen verschiedener Größe (2-200nm) verteilt
sind. Fluoreszenz- und elektronenmikroskopische Untersuchungen enthüllten, dass diese
Domänen in enger Nachbarschaft von Mannoserezeptoren (MR) liegen. Dieses Verteilungsmuster
von FcγRs und MRs führt zur Inhibierung der MR-vermittelten Phagozytose. Zusammenfassend
belegen die gewonnen Daten, dass es ein Zusammenspiel zwischen FcγR-vermittelter und
MR-vermittelter Phagozytose gibt.
[German] |
|
| document type: |
|
| institution: |
| Faculty of Mathematics and Natural Sciences |
|
| language: |
|
| subject class (DDC): |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2010
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000000556 |
| created / modified: |
09.03.2012 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
access
viewer
fulltext