| title: |
| A systems biology approach to dynamic modelling of the AMP-activated kinase pathway |
|
| contributing persons: |
| Simone Frey[VerfasserIn] |
 |
1014828619 |
| Olaf Wolkenhauer
, Prof. (PhD)[AkademischeR BetreuerIn] |
| Ursula Kummer
, Prof. Dr.[AkademischeR BetreuerIn] |
| Mattias Goksör
, Prof. Dr.[AkademischeR BetreuerIn] |
|
| contributing corporate bodies: |
| Universität Rostock, Fakultät für Informatik und Elektrotechnik[Grad-verleihende Institution] |
|
10085032-7 |
|
| |
| abstract: |
|
A systems biology approach is used to investigate a key regulator of energy sensing,
the AMPK/ Snf1 pathway. Therefore, a stimulus is derived considering transmembrane
glucose transport. Fluorescent microscopy data of Mig1, a Snf1 pathway component,
were processed through a mathematical approach. The data were compared to simulations
of alternative network structures suggested to underlie the Snf1 pathway. Certain
structures could be excluded. Besides, applying quantitative measures showed that
the design of a MAPK pathway is favourable for the transmission of fast signals with
short duration.
[English] |
|
| document type: |
|
| institution: |
| Faculty of Computer Science and Electrical Engineering |
|
| language: |
|
| subject class (DDC): |
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| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2011
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000000708 |
| created / modified: |
10.11.2011 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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