| title: |
| Wnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and
Wnt/β-catenin pathway |
|
| contributing persons: |
| Venkata Ajay Narendra Talabattula[VerfasserIn] |
 |
1129883426 |
| Arndt Rolfs
, MD PhD[AkademischeR BetreuerIn] |
|
136256864 |
|
University of Rostock, Albrecht Kossel Institut für Neuroregeneration |
| Gabriele M. Rune
, MD PhD[AkademischeR BetreuerIn] |
|
1027954480 |
|
Universitätsklinikum Hamburg-Eppendorf, Institut für Neuroanatomie |
| Hugo Murua Escobar
, PhD[AkademischeR BetreuerIn] |
|
University of Rostock, Zentrum für Innere Medizin |
|
| contributing corporate bodies: |
| Universität Rostock, Universitätsmedizin[Grad-verleihende Institution] |
|
1029510660 |
|
| |
| abstract: |
|
HumanNPCs (hNPCs) are the suitable cell source in translation medicine for neurodegenerative
disease. In the present study, effects of Wnt3a on the differentiation of hNPC were
studied. The results showed that Wnt3a induces canonical and non canonical Wnt pathways.
Furthermore, Wnt3a increases Ca2+ target genes CaMKII and Pyk2 in the differentiating
VM cells. The results demonstrated that Pyk2 decreases GSK3β activity and stabilizes
β-catenin, suggesting there is an intercross between Wnt/β-catenin and Wnt/Ca2+-pathway
via Pyk2.
[English] |
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| document type: |
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| institution: |
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| language: |
|
| subject class (DDC): |
| 610 Medical sciences Medicine |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2017
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000001706 |
| created / modified: |
11.04.2017 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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